Table 5 Characteristics of CADASIL patients with exon 11 variant and those with other variants.
From: Genetic and imaging features of CADASIL patients with acute ischemic stroke
Exon 11 (N = 39) | Others (N = 102) | p-value | |
|---|---|---|---|
Age at initial imaging (years) | 59.2 ± 10.3 | 52.1 ± 11.3 | 0.001 |
Male sex | 18 (46.2) | 39 (41.5) | 0.621 |
Risk factors | |||
Hypertension | 14 (35.9) | 12 (12.9) | 0.002 |
Diabetes mellitus | 9 (23.1) | 6 (6.4) | 0.006 |
Hypercholesterolemia | 11 (28.2) | 26 (27.7) | 0.949 |
Coronary heart disease | 4 (10.3) | 1 (1.1) | 0.026 |
Smoking history | 9 (23.1) | 25 (26.6) | 0.672 |
Family history of CADASIL | 8 (20.5) | 23 (24.5) | 0.623 |
Family history of stroke | 21 (53.8) | 64 (68.1) | 0.120 |
Presence of AIS | 13 (33.3) | 53 (56.4) | 0.016 |
SVD markers | |||
Presence of lacune | 30 (76.9) | 67 (72.0) | 0.562 |
Number of lacune | 3.9 ± 4.5 | 4.3 ± 4.8 | 0.721 |
Presence of CMB | 20 (60.6) | 43 (55.1) | 0.594 |
Number of CMB | 7.9 ± 14.0 | 4.5 ± 8.6 | 0.114 |
White matter hyperintensities | |||
Deep | 0.126 | ||
0–1 | 6 (15.4) | 10 (10.8) | |
2 | 11 (28.2) | 44 (47.3) | |
3 | 22 (56.4) | 39 (41.9) | |
Perivascular | 0.057 | ||
0–1 | 4 (10.3) | 6 (6.5) | |
2 | 3 (7.7) | 24 (25.8) | |
3 | 32 (82.1) | 63 (67.7) | |
Perivascular space (grade) | 0.128 | ||
0 | 7 (17.9) | 15 (16.1) | |
1 | 20 (51.3) | 63 (67.7) | |
2–4 | 12 (30.8) | 15 (16.1) | |
Anterior temporal pole lesions | 18 (46.2) | 54 (58.7) | 0.187 |
External capsule lesions | 34 (87.2) | 79 (85.9) | 0.842 |
