Fig. 5
From: A novel cardiomyopathy phenotype linked to a CHD7 missense variant
Altered ETS family transcription factor target gene expression in the hearts of CHD7 T730 missense mutant mice. (a) Overlap between CHD7 and ETS family transcription factor targets as reported in the Harmonizome database. The table shows the number of target genes for each transcription factor, the overlap with CHD7 targets, and the percentage of overlap. (b) Bar chart depicting enrichment scores for ETS family transcription factors targets among DEGs from homozygous Chd7T720A/T720A male and female neonatal hearts. (c) GSEA enrichment plots for RUNX1 upregulated target genes in the Chd7T720A/T720A transcriptome of male and female neonatal hearts. The NES values are displayed for male (NES = 1.35) and female (NES = 1.18).
