Table 9 Nine proteins differentially expressed in tug-of-war between diosmin and IAV, with specific roles in innate immune systems, determined by InnateDB.
From: Antiviral potential of diosmin against influenza A virus
Function | Gene name | Description | Up/down-regulated | InnateDB interactors |
|---|---|---|---|---|
The induction of type I interferon | UBE2N | Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity45 | Up | CHUK, IKBKB, IKBKG, ISG15, NFKB2, NFKBIA, RIPK1, TRAF1, TRAF2, TRAF3, TRAF6, UBE2V1 |
PSMA7 | Negative regulation of MAVS-mediated innate immune response by PSMA746 | Down | ISG15, MAVS, NFKB2, NFKBIA, TRAF2, TRAF3 | |
YWHAH | Promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution47 | Up | MAP3K3, MAP3K5, MAP3K6, MEFV, NFKBIA | |
YWHAQ | YWHAQ strongly enhanced the IFN-β promoter activity48 | Up | MAP3K3, MAP3K5, MAP3K6, MEFV | |
MAP3K14 | IKKα-mediated activation of IRF3/7 by MAP3K1436 | Up | CHUK, DDX58, IKBKAP, IKBKB, IKBKG, MAP3K8, NFKB2, RIPK1, TRAF1, TRAF2, TRAF3, TRAF6 | |
Anti-inflammatory response | GSTP1 | GSTP1-1 modulates TNF-a signaling49 | Up | ISG15, MAP3K5, NFKBIA, STAT3, TRAF2 |
HSPB1 | HSPB1 regulate TNF‐α, IL‐1β and IL‐1050 | Up | CHUK, IKBKB, MAP3K5, NFKBIA, STAT3 | |
PSMC2 | Involved in TNF-α/NF-κB signal transduction pathway51 | Up | NFKB2, NFKBIA, TRAF2, TRAF3, TRAF6 | |
VCP | VCP is a regulator of endoplasmic reticulum stress52 | Up | ISG15, NFKBIA, STAT3, TRAF6, UBE2V1, |
