Table 2 Multivariate Cox regression models between AISI with all-cause, cardiovascular and cardio-cerebrovascular mortality.

From: The aggregate index of systemic inflammation (AISI) and the risk of all-cause, cardiovascular, and cardio-cerebrovascular mortality in congestive heart failure patients: results from NHANES 1999–2018

 

Group1

HR

Group 2

HR (95%CI) P-value

Group 3

HR (95%CI) P-value

Group 4

HR (95%CI) P-value

All-cause mortality

    

Model1

1.00

1.056 (1.054, 1.057) *

1.167 (1.165, 1.168) *

2.211 (2.208, 2.213) *

Model2

1.00

0.937 (0.935, 0.938) *

1.057 (1.056, 1.058) *

1.710 (1.708, 1.712) *

Model3

1.00

0.925 (0.924, 0.927) *

1.010 (1.008, 1.011) *

1.599 (1.595, 1.602) *

Cardiovascular mortality

    

Model1

1.00

1.075 (1.073, 1.077) *

1.212 (1.210, 1.214) *

2.199 (2.195, 2.203) *

Model2

1.00

0.948 (0.946, 0.950) *

1.090 (1.088, 1.092) *

1.696 (1.693, 1.699) *

Model3

1.00

0.852 (0.850, 0.854) *

0.837 (0.835, 0.840) *

1.070 (1.066, 1.074) *

Cardio-cerebrovascular mortality

    

Model1

1.00

1.165 (1.163, 1.167) *

1.253 (1.251, 1.255) *

2.189 (2.185, 2.192) *

Model2

1.00

1.030 (1.028, 1.032) *

1.136 (1.134, 1.138) *

1.703 (1.700, 1.706) *

Model3

1.00

0.954 (0.952, 0.956) *

0.908 (0.906, 0.911) *

1.173 (1.168, 1.177) *

  1. CI Confidence interval, HR Hazard ratio, AISI: neutrophils(NEU) * platelets (PLT) * monocytes (MONO)/lymphocytes(LYM)).
  2. Model 1was adjusted for none.
  3. Model 2 was adjusted for age, gender, race, education, marital status.
  4. Model 3 was further adjusted for BMI, white blood cell, lymphocyte, monocyte, segmented neutrophils, hemoglobin, platelets, cholesterol, triglyceride, uric acid, creatinine, smoker, coronary heart disease, angina pectoris, stroke, hypertension, high cholesterol level, diabetes mellitus.
  5. *P < 0.00001.