Table 3 Threshold effect analysis of AISI on mortality using the two-piecewise regression model.

From: The aggregate index of systemic inflammation (AISI) and the risk of all-cause, cardiovascular, and cardio-cerebrovascular mortality in congestive heart failure patients: results from NHANES 1999–2018

 

All-cause mortality

HR (95%CI) P-value

Cardiovascular mortality

HR (95%CI) P-value

Cardio-cerebrovascular mortality HR (95%CI) P-value

Model I

   

One line

1.354 (1.065, 1.721) 0.0133

1.294 (0.933, 1.793) 0.1227

1.304 (0.964, 1.765) 0.0850

Model II

   

Inflection value

8.66

8.269

8.231

< threshold value

1.196 (0.930, 1.538) 0.1634

1.177 (0.853, 1.624) 0.3220

1.189 (0.870, 1.624) 0.2781

≥threshold value

2.262 (1.506, 3.395) < 0.0001

1.602 (1.075, 2.388) 0.0206

1.566 (1.072, 2.286) 0.0203

P for log-likelihood ratio

test †

0.002

0.132

0.166

  1. CI Confidence interval, HR Hazard ratio, AISI: neutrophils(NEU) * platelets (PLT) * monocytes (MONO)/lymphocytes(LYM)).
  2. AISI was log2-transformed to fit the Cox regression model.
  3. Analysis was adjusted for gender, age, race, education level, marital status, body mass index, white blood cell, lymphocyte, monocyte, segmented neutrophils, hemoglobin, platelet, cholesterol, triglycerides, uric acid, creatinine, smokers, coronary heart disease, angina pectoris, stroke, hypertension, high cholesterol level, diabetes mellitus.
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