Table 4 Stratified association between AISI with all-cause, cardiovascular and cardio-cerebrovascular mortality by sex.

From: The aggregate index of systemic inflammation (AISI) and the risk of all-cause, cardiovascular, and cardio-cerebrovascular mortality in congestive heart failure patients: results from NHANES 1999–2018

 

Group 1

HR

Group 2

HR (95%CI)

Group 3

HR (95%CI)

Group 4

HR (95%CI)

P-value

Trend

All-cause mortality

     

Female

1.00

0.943 (0.941, 0.945) *

0.812 (0.810, 0.814) *

1.096 (1.092, 1.100) *

< 0.001

Male

1.00

0.813 (0.811, 0.814) *

0.967 (0.965, 0.969) *

1.448 (1.444, 1.452) *

< 0.001

Cardiovascular mortality

     

Female

1.00

0.795 (0.792, 0.797) *

0.430 (0.428, 0.431) *

0.629 (0.625, 0.633) *

< 0.001

Male

1.00

0.869 (0.866, 0.872) *

1.351 (1.346, 1.356) *

1.401 (1.394, 1.408) *

< 0.001

Cardio-cerebrovascular mortality

     

Female

1.00

0.848 (0.845, 0.851) *

0.494 (0.492, 0.496) *

0.627 (0.624, 0.631) *

< 0.001

Male

1.00

1.011 (1.008, 1.015) *

1.348 (1.343, 1.353) *

1.586 (1.578, 1.594) *

< 0.001

  1. CI confidence interval, HR hazard ratio, AISI: neutrophils(NEU) * platelets (PLT) * monocytes (MONO)/lymphocytes(LYM)).
  2. Analysis was adjusted for age, race, education level, marital status, smoker, BMI, white blood cell, lymphocyte, monocyte, segmented neutrophils, hemoglobin, platelets, cholesterol, triglyceride, uric acid, creatinine, coronary heart disease, angina pectoris, stroke, hypertension, high cholesterol level, diabetes mellitus.
  3. *P < 0.00001.
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