Fig. 5
Comparison of cell–cell communication between different cell types in the HDM-sensitized group (T) and the non-HDM-sensitized group (C). (a) Comparison of interaction number and strength between T and C groups. (b) Differences in the number and intensity of interactions between different cell types in groups T and C. The red and blue lines represent upward and downward changes in the T group, respectively. The arrow’s direction indicates where the interaction begins and ends. (c) Changes in signaling pathways in several cell types in group T versus group C. Cell types in the blue box (classical monocytes and B cells) only increase the intensity of efferent interactions in the MHC-II pathway. Cell types in the orange box (dendritic cells and monocytes) increase the intensity of both efferent and afferent interactions in the MHC-II pathway. Cell types in the green box (naïve CD4 + T cells) only increase the intensity of afferent interactions in the MHC-II pathway. The circle plot in the lower right corner depicts the direction of MHC-II characteristic pathway transmission among the five cell types. The colors represent distinct cell types, while the arrows indicate the direction in which the signal is transmitted.
