Fig. 12. | Scientific Reports

Fig. 12.

From: Unraveling the anti-tumor effects of midazolam in non-small cell lung cancer through the lncRNA XLOC_010706/miR-520d-5p/STAT3/autophagy pathway

Fig. 12.

Midazolam inhibits cell apoptosis and lncRNA-XLOC_010706/ miR-520d-5p/STAT3 expression in vivo. (A,B) TUNEL apoptosis assay with xenograft tumor samples revealed that midazolam facilitated the apoptosis and lncRNA-XLOC_010706 inhibited cell apoptosis of A549 cells in vivo. RT-qPCR and western-blot assay results showed that lncRNA-XLOC_010706 expression significantly decreased (C), miR-520d-5p expression significantly increased (D), and STAT3 mRNA (E) and protein (F) expression significantly decreased in midazolam group. n=3, *P<0.05, **P<0.01.

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