Fig. 3 | Scientific Reports

Fig. 3

From: Thioredoxin-1 inhibits NLRP3-mediated pyroptosis by regulating TXNIP in models of Alzheimer’s disease

Fig. 3

Trx-1 overexpression inhibited the activation of NLRP3 in the hippocampus of APP/PS1 mice. (A) The WB detection of NLRP3, caspase-1 and IL-1β in the hippocampus of APP/PS1 mice. (B) Gray scale analysis of NLRP3. (C) Gray scale analysis of caspase-1. (D) Gray scale analysis of IL-1β. Statistics were calculated using one-way ANOVA with Tukey’s multiple comparisons test and are presented as mean ± SD from three independent experiments (n = 5 in WT + AAV-Trx-1 and WT + AAV-Vector groups, n = 4 in APP/PS1 + AAV-Vector and APP/PS1 + AAV-Trx-1 groups). **P < 0.01, ***P < 0.001.

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