Fig. 2

Differential metabolic profiles of group J vs. group N based on non-targeted metabolomics. OPLS-DA scores: (A) negative ion model, (B) positive ion model. N, normal group; J, non-obese patient group. S-plots: (C) negative ion model, (D) positive ion model. The abscissa represents the co-correlation coefficient of principal component and metabolite, and the ordinate represents the correlation coefficient of principal component and metabolite. Points farther from the origin represent variables with a greater contribution to the observed variance. Volcano plots: (E) negative ion model, (F) positive ion model. The screening criteria were fold change (J/N) ≥ 1.50 or fold change (N/J) ≥ 0.67, and adjusted p-value ≤ 0.05. Blue represents a decrease, and red represents an increase.