Table 4 The associations between MTNR1B rs1387153, rs10830963 and GDM risk in the overall subjects.
From: MTNR1B variants increase gestational diabetes mellitus risk in young Chinese pregnant women
SNP | Genetic Models | Cases (freq) | Controls (freq) | Crude OR (95% CI) | Crude P | Adjusted OR (95% CI) | Adjusted P |
|---|---|---|---|---|---|---|---|
(n = 500( | (n = 502) | ||||||
rs1387153 | Codominant model | ||||||
CC | 107 (0.214) | 146 (0.291) | 1 (ref) | 1 (ref) | |||
CT | 259 (0.518) | 259 (0.516) | 1.364 (1.008–1.848) | 0.044 | 1.490 (1.083–2.050) | 0.014 | |
TT | 134 (0.268) | 97 (0.193) | 1.885 (1.313–2.705) | 0.001 | 1.857 (1.271–2.712) | 0.001 | |
Aelle model | |||||||
C | 473 (0.473) | 551(0.549) | 1 (ref) | 1 (ref) | |||
T | 527 (0.527) | 453 (0.451) | 1.355 (1.137–1.615) | 0.001 | 1.347 (1.121–1.619) | 0.002 | |
Dominant Model | |||||||
CC | 107 (0.214) | 146 (0.291) | 1 (ref) | 1 (ref) | |||
TT + CT | 393 (0.786) | 356 (0.709) | 1.506 (1.130–2.008) | 0.005 | 1.595 (1.178–2.160) | 0.003 | |
Recessive Model | |||||||
CT + CC | 366 (0.732) | 405 (0.807) | 1 (ref) | 1 (ref) | |||
TT | 134 (0.268) | 97 (0.193) | 1.529 (1.136–2.057) | 0.005 | 1.421 (1.041–1.939) | 0.027 | |
rs10830963 | Codominant model | ||||||
CC | 117 (0.234) | 168 (0.335) | 1 (ref) | 1 (ref) | |||
CG | 254 (0.508) | 251 (0.500) | 1.453 (1.084–4.949) | 0.013 | 1.501 (1.104–2.042) | 0.010 | |
GG | 129 (0.258) | 83 (0.165) | 2.232 (1.552–3.208) | < 0.001 | 2.087 (1.428–3.051) | < 0.001 | |
Aelle model | |||||||
C | 488 (0.488) | 587 (0.585) | 1 (ref) | 1 (ref) | |||
G | 512 (0.512) | 417 (0.415) | 1.477 (1.238–1.762) | < 0.001 | 1.435 (1.193–1.726) | < 0.001 | |
Dominant Model | |||||||
CC | 117 (0.234) | 168 (0.335) | 1 (ref) | 1 (ref) | |||
GG + CG | 383 (0.766) | 334 (0.665) | 1.647 (1.247–2.174) | < 0.001 | 1.653 (1.235–2.212) | 0.001 | |
Recessive Model | |||||||
CG + CC | 371 (0.742) | 419 (0.835) | 1 (ref) | 1 (ref) | |||
GG | 129 (0.258) | 83 (0.165) | 1.755 (1.288–2.391) | < 0.001 | 1.607 (1.164–2.220) | 0.004 |
