Table 7 Haplotype analysis of the rs1387153 and rs10830963 SNPs of the MTNR1B gene for the GDM and controls.
From: MTNR1B variants increase gestational diabetes mellitus risk in young Chinese pregnant women
Group | Haplotype | Cases (freq) | Controls (freq) | χ2 | P | OR (95% CI) |
|---|---|---|---|---|---|---|
Overall | CC | 423 (0.423) | 510 (0.507) | 14.536 | < 0.001 | 0.710 (0.595–0.846) |
TG | 462 (0.462) | 376 (0.374) | 15.764 | < 0.001 | 1.434 (1.200–1.714) | |
CG | 50 (0.05) | 41 (0.04) | 0.97 | 0.324 | 1.236 (0.810–1.886) | |
TC | 65 (0.065) | 77 (0.076) | 1.04 | 0.307 | 0.836 (0.594–1.178) | |
Age < 30 | CC | 161 (0.417) | 320 (0.528) | 11.622 | < 0.001 | 0.639 (0.494–0.827) |
TG | 182 (0.471) | 212 (0.349) | 14.578 | < 0.001 | 1.658 (1.277–2.151) | |
CG | 17 (0.044) | 25 (0.041) | 0.045 | 0.831 | 1.070 (0.570–2.009) | |
TC | 26 (0.067) | 49 (0.08) | 0.614 | 0.432 | 0.82 (0.501–1.345) | |
Age ≥ 30 | CC | 262 (0.426) | 190 (0.477) | 2.509 | 0.113 | 0.814 (0.632–1.049) |
TG | 280 (0.456) | 164 (0.412) | 1.895 | 0.168 | 1.196 (0.926–1.543) | |
CG | 33 (0.053) | 16 (0.04) | 0.961 | 0.326 | 1.356 (0.736–2.497) | |
TC | 39 (0.063) | 28 (0.07) | 0.182 | 0.669 | 0.896 (0.542–1.481) |
