Table 1 Differences in peripheral blood indices and inflammatory indices between AD group and control group.

From: Association of red blood cell count, hemoglobin concentration, and inflammatory indices with cognitive impairment severity in Alzheimer’s disease

Variable

AD group (N = 225)

Control group (N = 2000)

t/χ2/Z

P value

Effect sizes Cohen’s d/φ (Phi)

Age

76(70.5 ~ 80.5)

75(71 ~ 78)

− 0.63

1

0.02

Gender

3.95

0.94

0.04

 Male, n (%)

97(43.1%)

1002(50.1%)

   

 Female, n (%)

128(56.9%)

998(49.9%)

   

 BMI, kg/m2

21.45 (19.02 ~ 24.05)

22.4(20.73 ~ 23.7)

− 2.71

0.14

0.12

Diabetes

36.71

 < 0.001***

0.13

 Yes, n (%)

51(22.7%)

189(9.4%)

   

 No, n (%)

174(77.3%)

1811(90.6%)

   

Hypertension

35.14

 < 0.001***

0.13

 Yes, n (%)

144(64%)

865(43.3%)

   

 No, n (%)

81(36%)

1135(56.7%)

   

WBC count (*10^9/L)

5.13(4.16 ~ 6.16)

5.66(4.8 ~ 6.70)

− 4.98

 < 0.001***

0.32

Neutrophil count (*10^9/L)

3.27(2.42 ~ 4.04)

3.19(2.61 ~ 3.96)

− 0.18

1

0.06

Lymphocyte count (*10^9/L)

1.36(1.05 ~ 1.73)

1.83(1.48 ~ 2.27)

− 11.76

 < 0.001***

0.86

Monocyte count (*10^9/L)

0.34(0.26 ~ 0.41)

0.34(0.27 ~ 0.42)

− 0.31

1

0.03

Eosinophil count (*10^9/L)

0.1(0.05 ~ 0.16)

0.13(0.08 ~ 0.21)

− 6.62

 < 0.001***

0.42

Basophil count (*10^9/L)

0.01(0.01 ~ 0.02)

0.02(0.01 ~ 0.03)

− 10.78

 < 0.001***

0.48

RBC count (*10^12/L)

4(3.74 ~ 4.27)

4.52(4.23 ~ 4.79)

− 14.18

 < 0.001***

1.09

HB concentration (g/L)

124(115 ~ 132.5)

140(131 ~ 148)

− 15.18

 < 0.001***

1.16

Platelet count (*10^9/L)

193(156 ~ 238.5)

188(159 ~ 221)

− 1.34

1

0.14

NLR

2.31 (1.64 ~ 3.25)

1.75 (1.32 ~ 2.29)

− 8.57

 < 0.001***

0.60

PLR

141.86 (103.91 ~ 192.09)

102.06 (80.25 ~ 127.83)

− 11.11

 < 0.001***

0.83

MLR

0.24 (0.18 ~ 0.33)

0.18 (0.14 ~ 0.24)

− 9.76

 < 0.001***

0.70

SII

450.51(287.73 ~ 682.98)

325.93(233.41 ~ 447.18)

− 7.62

 < 0.001***

0.57

SIRI

0.74 (0.49 ~ 1.17)

0.58 (0.41 ~ 0.85)

− 5.97

 < 0.001***

0.46

PIV

145.95(84.14 ~ 265.09)

109.60(70.93 ~ 165.88)

− 5.80

 < 0.001***

0.44

  1. AD Alzheimer’s disease, BMI body mass index, WBC white blood cell, RBC red blood cell, HB hemoglobin, NLR neutrophil/lymphocyte ratio, PLR platelet/lymphocyte ratio, MLR monocyte/lymphocyte ratio, SII systemic immune inflammation index, SIRI systemic inflammation response index, PIV pan-immune-inflammation value.
  2. Non-normally distributed continuous variables were summarized using median with interquartile range (25th-75th percentiles).
  3. *P < 0.05, **P < 0.01, ***P < 0.001.
Back to article page