Fig. 3

Forest plot of univariable MR causal associations of MN on 10 candidate mediators. Different methods were used to obtain beta values and 95% confidence intervals. MMP12, Matrix metalloproteinase-12; TM, Thrombomodulin; TF, Tissue factor; MCSF1, Macrophage colony-stimulating factor 1; IL-1β, Interleukin-1 beta; CRP, C-reactive protein; CD4, T-cell surface glycoprotein CD4; BNGF, Beta-nerve growth factor; HGF, Hepatocyte growth factor; SCF, Stem cell factor; β effect size for the effect allele; FDR-P P value of False Discovery Rate.