Table 2 Estimates for the causal associations of candidate mediators on PAD with adjustment for MN by MVMR-IVW.

From: Trans-ethnic Mendelian randomization analysis of membranous nephropathy and peripheral artery disease with mediating effects of thrombomodulin

Candidate mediator

Outcome

nSNP

β (95% CI)

OR (95% CI)

P value

TM

PAD-dis

2

0.225(0.135, 0.297)

1.252(1.116, 1.346)

8.58E-10

TF

PAD-dis

7

−0.022(−0.132, 0.092)

0.978(0.873, 1.096)

7.08E-01

MCSF1

PAD-dis

1

−0.047(−0.090, −0.004)

0.955(0.914, 0.996)

3.35E-02

IL-1β

PAD-dis

1

0.166(0.099, 0.234)

1.181(1.104, 1.264)

1.34E-06

HGF

PAD-dis

2

0.220(0.035, 0.406)

1.246(1.035, 1.501)

2.00E-02

SCF

PAD-dis

11

−0.180(−0.407, 0.047)

0.835(0.666, 1.048)

1.20E-01

TM

PAD-val

2

0.365(0.223, 0.506)

1.440(1.250, 1.658)

4.20E-07

  1. Notes: PAD, Peripheral artery disease; MN, Membranous nephropathy; MVMR-IVW, multivariable Mendelian randomization inverse variance weighted; TM, Thrombomodulin; TF, Tissue factor; MCSF1, Macrophage colony-stimulating factor 1; IL-1β, Interleukin-1 beta; HGF, Hepatocyte growth factor; SCF, Stem cell factor; dis, discovery; val, validation.
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