Table 3 A3-coupling reaction with various types of aldehydes,andamines catalyzed with Zn-MOF-NH2-ZIF-8@Cu systema.

From: Synthesis and characterization of novel nanomaterial Zn-MOF-NH2-ZIF-8@Cu based on MOF-on-MOF architecture and Cu nanoparticle as a stable nanocatalyst in solvent-free A3 coupling reaction

Entry

Amine

Aldehydes

Product

Time

(min)

Yield

(%) b

1

Morpholine

15

95

2

Piperidin

15

96

3

Morpholine

35

93

4

Piperidin

20

90

5

Morpholine

35

90

6

Piperidin

20

90

7

Morpholine

35

90

8

Morpholine

50

85

9

Piperidin

45

85

10

Morpholine

10

98

11

Piperidin

10

98

12

Piperidin

65

85

13

Morpholine

80

85

  1. aAll reactions were carried out with 1.5 mmol of phenyl acetylene, 1.2 mmol of amines, 1 mmol of aldehydes, and 0.72 mol% of Zn-MOF-NH2-ZIF-8@Cu under N2 atmosphere and solvent-free condition. bYield refer to isolated pure products.
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