Fig. 3
From: rhaFGF promotes acute diabetic wound healing by suppressing chronicity of inflammation
The effects of rhaFGF on the proliferation of HUVEC, HFF and HaCat cells under control and HG + LPS conditions. The cells were incubated with rhaFGF for 48 h and cell proliferation was assessed by CCK-8 assay. A. proliferation following 48 h of incubation with various rhaFGF concentrations in normal culture medium (n = 3/group). rhaFGF treatment increased the proliferation of HUVEC (A), HFF (B) HaCat (C) under control condition in a dose-dependent manner(n = 3/group), The proliferation of HFF (D), HUVEC (E), HaCat (F) were inhibited under diabetic inflammatory conditions mimicked by high glucose and LPS-induced inflammation and rhaFGF treatment (optimal rhaFGF concentration of 20ng/ml,5ng/ml and 50ng/ml respectively) partially reversed this inhibition (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.
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