Fig. 3 | Scientific Reports

Fig. 3

From: Assessing individual head and neck squamous cell carcinoma patient response to therapy through integration of functional and genomic data

Fig. 3

Drug response in the HNSCC cohort is consistent with large-scale cell line screens. Patient samples and GDSC cells lines were clustered according to alterations associated with drug response to one of the common inhibitors between the HNSCC cohort and GDSC. (a) Shown is a matrix plot where columns (samples or cell lines) and alterations (rows) are clustered based on their Jaccard distance. Purple indicates that the patient sample or cell line has the corresponding alteration. Only those patient samples (bold) or cell lines with at least one alteration are shown. Note that patient sample 10250 and 10356 have no matching cell lines based on their mutation profile. Pearson’s correlation was computed between the normalized AUC values for each patient sample and the AUCs of the matching inhibitors in GDSC. (b) Scatterplots of the AUC values for the matching drugs between the HNSCC cohort and GDSC are provided. Each scatterplot is faceted by patient sample id and the corresponding best GDSC cell line name (boxes on the top). The text indicates the Pearson’s correlation. Unadjusted significance is indicated by P-value: < 0.001 ***, < 0.01 ** < 0.05 *.

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