Table 2 Association of serum α-klotho/100 level (pg/mL) with BMD (g/cm2) among CKD patients.

From: Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016

Characteristics

Model I

β (95% CI) p value

Model II

β (95% CI) p value

Model III

β (95% CI) p value

Left Leg BMD

   

 α-klotho/100

-0.000 (-0.003, 0.003) 0.88278

-0.002 (-0.004, 0.001) 0.21600

0.001 (-0.001, 0.004) 0.29042

 α-klotho/100 quartile

   

 Q1

Reference

Reference

Reference

 Q2

0.013 (-0.013, 0.040) 0.33234

0.000 (-0.021, 0.022) 0.97170

0.016 (-0.004, 0.036) 0.12722

 Q3

-0.006 (-0.033, 0.022) 0.69249

-0.015 (-0.036, 0.007) 0.19509

0.004 (-0.016, 0.025) 0.69503

 Q4

-0.005 (-0.032, 0.022) 0.70829

-0.009 (-0.030, 0.013) 0.43242

0.020 (-0.002, 0.041) 0.07286

 p for trend

0.43060

0.24291

0.17518

Thoracic Spine BMD

   

 α-klotho/100

0.002 (-0.001, 0.005) 0.21905

0.001 (-0.002, 0.004) 0.64921

0.004 (0.002, 0.007) 0.00264**

 α-klotho/100 quartile

   

 Q1

Reference

Reference

Reference

 Q2

0.018 (-0.009, 0.044) 0.18677

0.011 (-0.013, 0.035) 0.36216

0.028 (0.006, 0.050) 0.01342*

 Q3

0.017 (-0.010, 0.044) 0.21758

0.009 (-0.015, 0.034) 0.46675

0.036 (0.013, 0.059) 0.00210**

 Q4

0.015 (-0.011, 0.042) 0.25790

0.010 (-0.014, 0.035) 0.41653

0.048 (0.024, 0.071) 0.00010**

 p for trend

0.29512

0.47714

0.00010**

Lumbar Spine BMD

   

 α-klotho/100

-0.002 (-0.005, 0.002) 0.39635

-0.002 (-0.005, 0.002) 0.32106

0.001 (-0.002, 0.005) 0.41913

 α-klotho/100 quartile

   

 Q1

Reference

Reference

Reference

 Q2

0.002 (-0.027, 0.031) 0.88644

-0.000 (-0.030, 0.029) 0.97429

0.012 (-0.017, 0.041) 0.42270

 Q3

-0.025 (-0.055, 0.005) 0.10457

-0.025 (-0.055, 0.005) 0.09939

-0.008 (-0.037, 0.022) 0.61632

 Q4

-0.016 (-0.045, 0.014) 0.30570

-0.015 (-0.044, 0.015) 0.32822

0.013 (-0.018, 0.044) 0.39895

 p for trend

0.12662

0.14949

0.69423

Pelvis BMD

   

 α-klotho/100

0.000 (-0.003, 0.004) 0.85346

-0.001 (-0.004, 0.002) 0.55457

0.002 (-0.002, 0.006) 0.27368

 α-klotho/100 quartile

   

 Q1

Reference

Reference

Reference

 Q2

0.026 (-0.004, 0.056) 0.09480

0.014 (-0.014, 0.043) 0.32663

0.021 (-0.007, 0.050) 0.14355

 Q3

-0.000 (-0.032, 0.031) 0.97884

-0.006 (-0.036, 0.023) 0.66978

0.008 (-0.021, 0.038) 0.58062

 Q4

0.012 (-0.019, 0.043) 0.44635

0.003 (-0.027, 0.032) 0.86338

0.028 (-0.003, 0.059) 0.07355

 p for trend

0.84835

0.77424

0.15576

Trunk Bone BMD

   

 α-klotho/100

0.001 (-0.001, 0.004) 0.33793

0.000 (-0.002, 0.003) 0.81800

0.002 (0.000, 0.005) 0.03708*

 α-klotho/100 quartile

   

 Q1

Reference

Reference

Reference

 Q2

0.016 (-0.005, 0.037) 0.12646

0.011 (-0.008, 0.030) 0.26402

0.019 (0.001, 0.038) 0.04160*

 Q3

0.009 (-0.013, 0.030) 0.42457

0.004 (-0.015, 0.023) 0.67417

0.017 (-0.002, 0.036) 0.07807

 Q4

0.009 (-0.012, 0.030) 0.40518

0.005 (-0.014, 0.024) 0.59924

0.025 (0.006, 0.045) 0.01224*

 p for trend

0.57569

0.78498

0.02110*

Total BMD

   

 α-klotho/100

0.001 (-0.002, 0.003) 0.62127

0.000 (-0.002, 0.003) 0.88374

0.003 (0.000, 0.005) 0.02591*

 α-klotho/100 quartile

   

 Q1

Reference

Reference

Reference

 Q2

0.006 (-0.017, 0.029) 0.61728

0.003 (-0.017, 0.024) 0.74135

0.009 (-0.010, 0.029) 0.35503

 Q3

0.003 (-0.021, 0.026) 0.83553

-0.005 (-0.026, 0.017) 0.67061

0.007 (-0.013, 0.028) 0.48952

 Q4

0.003 (-0.020, 0.026) 0.79304

0.006 (-0.015, 0.027) 0.57690

0.029 (0.007, 0.050) 0.00845**

 p for trend

0.88307

0.76385

0.01561*

  1. Regression coefficients represent the change in BMD (g/cm2) per 100 pg/mL increase in serum α-Klotho concentration. *p < 0.05, **p < 0.01 Model I: no covariates were adjusted; Model II: race, age, gender were adjusted; Model III: race, gender, age, education, income poverty ratio, alcohol, smoking, ALP, AST, ALT, total calcium, creatinine, globulin, phosphorus, hypertension, BMI, HGB, PLT, Hba1c, physical activity, dietary vitamin D, dietary calcium and 25(OH)vitamin D were adjusted.
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