Table 3 Associations between serum α-klotho/100 (pg/mL) and BMD (g/cm2) by gender, age, race, BMI, diabetes and hypertension.
Left Leg BMD | Thoracic Spine BMD | Lumbar Spine BMD | Pelvis BMD | Trunk Bone BMD | Total BMD | |
|---|---|---|---|---|---|---|
Gender | ||||||
Male | 0.004 (-0.001, 0.009) 0.1127 | 0.009 (0.003, 0.015) 0.0016* | 0.005 (-0.002, 0.012) 0.1681 | 0.004 (-0.003, 0.012) 0.2487 | 0.005 (0.000, 0.009) 0.0493 | 0.003 (-0.002, 0.008) 0.2952 |
Female | 0.001 (-0.002, 0.004) 0.4496 | 0.004 (0.000, 0.007) 0.0280* | 0.001 (-0.003, 0.005) 0.6634 | 0.001 (-0.003, 0.005) 0.6446 | 0.002 (-0.001, 0.005) 0.1370 | 0.003 (0.000, 0.006) 0.0225* |
p for interaction | 0.2855 | 0.0821 | 0.2982 | 0.4134 | 0.3099 | 0.8390 |
Age(Year) | ||||||
≤50 | 0.001 (-0.002, 0.004) 0.6415 | 0.004 (0.001, 0.008) 0.0185* | 0.003 (-0.002, 0.008) 0.2412 | 0.002 (-0.003, 0.007) 0.3531 | 0.003 (0.000, 0.006) 0.0326* | 0.003 (-0.001, 0.006) 0.1125 |
>50 | 0.001 (-0.003, 0.005) 0.6624 | 0.004 (-0.001, 0.008) 0.0970 | 0.000 (-0.005, 0.005) 0.9991 | 0.003 (-0.002, 0.009) 0.2804 | 0.001 (-0.002, 0.005) 0.4332 | 0.002 (-0.002, 0.005) 0.4367 |
p for interaction | 0.9762 | 0.7532 | 0.4221 | 0.8333 | 0.3943 | 0.6470 |
Race | ||||||
Mexican American | -0.006 (-0.017, 0.005) 0.3066 | -0.003 (-0.016, 0.009) 0.5994 | -0.005 (-0.021, 0.012) 0.5607 | -0.005 (-0.021, 0.011) 0.5480 | -0.003 (-0.014, 0.007) 0.5237 | -0.002 (-0.013, 0.008) 0.6577 |
Other Hispanic | 0.001 (-0.016, 0.018) 0.9059 | 0.002 (-0.017, 0.020) 0.8719 | -0.003 (-0.027, 0.021) 0.8175 | 0.016 (-0.007, 0.039) 0.1796 | 0.003 (-0.013, 0.018) 0.7316 | -0.001 (-0.018, 0.017) 0.9253 |
Non-Hispanic White | 0.004 (0.001, 0.008) 0.0239* | 0.007 (0.003, 0.011) 0.0007** | 0.004 (-0.001, 0.009) 0.1196 | 0.003 (-0.002, 0.008) 0.2248 | 0.004 (0.001, 0.008) 0.0107* | 0.005 (0.002, 0.009) 0.0027** |
Non-Hispanic Black | -0.005 (-0.013, 0.004) 0.2623 | 0.002 (-0.008, 0.011) 0.7429 | -0.001 (-0.013, 0.011) 0.8509 | -0.005 (-0.016, 0.006) 0.3835 | -0.002 (-0.009, 0.006) 0.6859 | -0.005 (-0.014, 0.003) 0.2209 |
Other Race | 0.003 (-0.009, 0.015) 0.5866 | 0.001 (-0.012, 0.015) 0.8287 | 0.001 (-0.016, 0.019) 0.8873 | 0.004 (-0.013, 0.021) 0.6296 | 0.002 (-0.009, 0.013) 0.7249 | 0.003 (-0.009, 0.014) 0.6575 |
p for interaction | 0.0668 | 0.2628 | 0.6370 | 0.2259 | 0.2754 | 0.0380* |
BMI | ||||||
≤ 24.9 | 0.001 (-0.006, 0.008) 0.7805 | 0.002 (-0.006, 0.011) 0.6121 | 0.000 (-0.011, 0.011) 0.9709 | 0.002 (-0.009, 0.012) 0.7631 | 0.001 (-0.006, 0.007) 0.8294 | 0.001 (-0.006, 0.008) 0.8515 |
> 24.9, ≤ 29.9 | 0.000 (-0.005, 0.006) 0.8913 | -0.001 (-0.007, 0.005) 0.7799 | -0.004 (-0.012, 0.003) 0.2404 | -0.002 (-0.009, 0.005) 0.6127 | -0.000 (-0.005, 0.004) 0.9153 | -0.001 (-0.006, 0.004) 0.7444 |
> 29.9 | -0.000 (-0.004, 0.003) 0.8520 | 0.005 (0.001, 0.010) 0.0187* | 0.002 (-0.003, 0.008) 0.3721 | 0.002 (-0.003, 0.008) 0.3801 | 0.002 (-0.001, 0.005) 0.2321 | 0.002 (-0.002, 0.006) 0.3611 |
p for interaction | 0.9209 | 0.1905 | 0.2536 | 0.5769 | 0.6665 | 0.6505 |
Diabetes | ||||||
No | 0.000 (-0.002, 0.003) 0.7576 | 0.004 (0.001, 0.007) 0.0074** | 0.000 (-0.003, 0.004) 0.8663 | 0.002 (-0.002, 0.006) 0.3099 | 0.002 (-0.000, 0.005) 0.0763 | 0.002 (-0.000, 0.005) 0.0940 |
Yes | 0.002 (-0.018, 0.021) 0.8585 | 0.001 (-0.015, 0.016) 0.9025 | 0.000 (-0.019, 0.020) 0.9921 | 0.003 (-0.016, 0.023) 0.7396 | 0.003 (-0.010, 0.016) 0.6396 | -0.000 (-0.021, 0.020) 0.9670 |
p for interaction | 0.8845 | 0.6756 | 0.9801 | 0.8859 | 0.8950 | 0.7859 |
Hypertension | ||||||
No | 0.001 (-0.003, 0.004) 0.6917 | 0.005 (0.002, 0.009) 0.0029** | 0.003 (-0.002, 0.007) 0.2267 | 0.004 (-0.000, 0.009) 0.0771 | 0.003 (0.000, 0.006) 0.0280* | 0.002 (-0.001, 0.005) 0.2454 |
Yes | -0.000 (-0.005, 0.004) 0.8664 | -0.002 (-0.007, 0.004) 0.5469 | -0.002 (-0.009, 0.005) 0.5585 | -0.004 (-0.010, 0.003) 0.2685 | -0.001 (-0.005, 0.003) 0.5955 | 0.001 (-0.003, 0.006) 0.5457 |
p for interaction | 0.6932 | 0.0177* | 0.2064 | 0.0386* | 0.0677 | 0.8703 |
