Fig. 4 | Scientific Reports

Fig. 4

From: Strictosamide and mitraphylline inhibit cancer cell motility by suppressing epithelial-mesenchymal transition via integrin α4-mediated signaling

Fig. 4

Strictosamide (1) and mitraphylline (2) downregulated several cell motility-related factors. (A) Pathway-focused gene expression analysis using the Human Cell Motility RT2 Profiler™ PCR Array was performed to examine the mechanisms by which strictosamide and mitraphylline modulate cell motility. The scatter plot compares the gene on the PCR Array between the DMSO-strictosamide and DMSO-mitraphylline. The number of fold changes for ITGA4 arranged downwards is shown in the figure. (B) A network of interrelated genes affected by strictosamide (1) and mitraphylline (2). (C) Quantitative analysis of the mRNA expressions of CAV1, CAPN1, WASF1, WASL, RHO, RHOA, RHOB, ITGA4, FAK, SRC in H1975, AGS, and CaCo2 cells treated with 2.5 µM of strictosamide (1) and mitraphylline (2). Data are represented as the mean ± S.D. * p < 0.05; ** p < 0.01; *** p < 0.001.

Back to article page