Fig. 7 | Scientific Reports

Fig. 7

From: Synthesis and antimicrobial activity of thiophene-functionalized Ag(I) and Au(I) N-heterocyclic carbene complexes against ampicillin-resistant Staphylococcus aureus

Fig. 7

Biofilm eradication and mechanism of action of Au(I)-NHC complexes against S. aureus. (A) Crystal violate assay of 2b in combination with ampicillin. Untreated S. aureus cells and 1% Triton X-100 are used as negative and positive controls, respectively. (B) ATP release determination from ampicillin-resistant S. aureus upon treatment with Au(I)-NHC complexes, 1b, and 2b. Untreated S. aureus cells were used as control. (C) SEM images of ampicillin-resistant S. aureus after 30 min of treatment with 2b alone. Untreated S. aureus cells were used as control (i). Bars showed a standard deviation (SD) while statistical significance is considered acceptable when P < 0.05.

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