Fig. 3 | Scientific Reports

Fig. 3

From: A novel isoquinoline mitophagy inducer ameliorates paclitaxel-induced peripheral neuropathy in Drosophila and mouse models

Fig. 3

Therapeutic effects of ALT001 on paclitaxel-induced heat hyperalgesia in a Drosophila larval model are independent of ATG5 and ATG7. (A–B) Drosophila L3 larvae expressing control RNAi (CON RNAi), and ATG5 RNAi (A), or ATG7 RNAi (B) were expose to paclitaxel (20 µM) either alone or in combination with ALT001 (750 µM) for 48 h, and a thermal nociception assay was performed with a 40 °C heat probe (n ≧ 40 per sample). Significance was assessed using one-way ANOVA followed by Šidák’s multiple-comparison test. ***p < 0.001. NS, not significant.

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