Fig. 1

Screening and functional analysis of candidate genes (a) Volcanic diagram of DEGs expression between disease group and control group. Green represented up-regulated differential genes, orange represented down-regulated differential genes (b) Heat map of DEGs expression between the disease group and the control group. Green indicated high expression, and orange indicated low expression. (c) Venn diagram of candidate gene set obtained by intersection of DEGs and CMRGs (d) GO enrichment map of candidate gene, The larger the bubble was, the greater the number of genes enriched in this pathway was. (e) KEGG enrichment map of candidate gene. The colored bands in the circles corresponded to the pathway colors in the legend below the figure. (f) The PPI network analysis of the candidate genes. The higher the degree of interaction was, the yellower the color of the nodes was.