Table 1 Baseline characteristics of the adherence and nonadherent groups.

From: Risk factors and reasons for romosozumab nonadherence in a case-control study

 

Adherence (n = 62)

Nonadherence (n = 69)

p-value

Age at first treatment (years)

73.9 ± 10.9

74.6 ± 11.5

0.721a

 < 60 years

8 (12.9%)

5 (7.2%)

0.464

 60–69 years

12 (19.4%)

13 (18.8%)

 70–79 years

18 (29.0%)

28 (40.6%)

 ≥ 80 years

24 (38.7%)

23 (33.3%)

Sex

 Female

61 (98.4%)

56 (81.2%)

0.001

 Male

1 (1.6%)

13 (18.8%)

Bone mass density (T-score)b

− 3.3 ± 0.9

− 3.1 ± 0.9

0.320

Romosozumab expenses

 Full subsidy

27 (43.5%)

15 (21.7%)

0.008

 Self-payment

35 (56.5%)

54 (78.3%)

 Fracture history within 1 year before romosozumab therapy

17 (27.4%)

12 (17.4%)

0.167

History of orthopedic surgery

 None

32 (51.6%)

35 (50.7%)

0.741

 Within 1 year before treatment

26 (41.9%)

27 (39.1%)

 During treatment

4 (6.5%)

7 (10.1%)

  1. aMann-Whitney U test.
  2. bData were missing for five patients in the nonadherent group. T-score: the lowest value among the lumbar spine L1–L4, total hip, or femoral neck.