Fig. 1

Landscape of differential expression genes analysis and Partial Least-Square Discriminant Analysis (PLS-DA). (A) PLS-DA score plot for transcriptomics data, resulting in severity separation along principal component 1 (PC1-22.3%) is presented (B) Volcano plot of differentially expressed genes between COVID-19 transcriptomic profiles of different severity groups of patients showing fold change for each gene and their significance level. Colored dots show genes with an adjusted P-value < 0.05 and an absolute log₂ (fold change) > 1. Blue dots represent down-regulated genes, and red dots represent up-regulated genes. Venn diagrams demonstrates the number of overlapping (C) Differentially up regulated genes, and (D) Differentially down regulated genes expressed between COVID-19 subjects.