Fig. 2 | Scientific Reports

Fig. 2

From: Immune transcriptomic analysis on COVID-19 patients with varying clinical presentations identifies severity markers

Fig. 2The alternative text for this image may have been generated using AI.

Comparing differently changed genes. A. Gene expression of several key proteins. Dot plot displaying the normalized count of ACE2, TMPRSS2 SARS-CoV-2 entry proteins expression, ARG1, FOXP3, CRTAM, FADD, HGF and IL-10 key proteins expression. Asterisks show significant difference (one-way anova test, Significance codes: >0.05 ‘ns’, < 0.05 ‘*’, < 0.01 ‘**’, < 0.001 ‘***’, 0 ‘****’). Points represent individual patient data. P-values were calculated using a two-tailed Wilcoxon test. B. VIP represents the contribution score of the DEGs that mostly contribute to the differentiation between COVID-19 patients severity groups. The top 30 discriminatory genes are listed from top to bottom, ranked by their VIP scores ≥ 1.3. Changes in expression for each gene are presented, wherein blue: represents decrease and red: represents increase in transcript expression.

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