Fig. 5

Estimated circulating immune cell populations. Proportions of circulating immune cell populations estimated from transcriptome data. (A) The average proportion of blood cells were predicted from transcriptome data using a deconvolution algorithm. (B) Lymphocyte subpopulations expressed as proportion of the absolute number of lymphocytes. (C) Natural killer cell subpopulations expressed as proportion of the absolute number of natural killer cells. (D) The proportion of neutrophils and the neutrophil to lymphocyte ratio (NLR) predicted from transcriptome data. The proportion of lymphocyte corresponds to the sum of proportions of T cells, B cells, and NK cells. Asterisks show significant difference (one-way anova test, Significance codes: >0.05 ‘ns’, < 0.05 ‘*’, < 0.01 ‘**’, < 0.001 ‘***’, 0 ‘****’). Points represent individual patient data. P-values were calculated using a two-tailed Wilcoxon test.