Fig. 2

Mß-CD inhibited lipids and cholesterol substances levels and lowered plasma IL-1ß and IL-18 in ApoE^−/− mice. (A–D) The graphs show that ApoE^−/− mice on the high-fat diet had significantly higher plasma levels of TG, TCHO, LDL-c, and blood glucose compared to both the wild-type and ApoE^−/− +Mß-CD groups. (E) The wild-type and ApoE^−/−+Mß-CD groups exhibited significantly higher HDL-c levels. (F–G) Similarly, plasma levels of the inflammatory mediators IL-1ß and IL-18 were significantly reduced in both the wild-type and ApoE^−/−+Mß-CD groups. Statistical analysis revealed significant differences between the ApoE^−/−, wild-type, and ApoE^−/− +Mß-CD groups (n = 8, *P < 0.05, **P < 0.01).