Fig. 6 | Scientific Reports

Fig. 6

From: Inhibition of levodopa metabolism to dopamine by honokiol short-chain fatty acid derivatives may enhance therapeutic efficacy in Parkinson’s disease

Fig. 6

Effect of HNK-SCFA-esters on L-dopa degradation by E. faecalis. E. faecalis was treated with HNK-Ac (A), HNK-PAc (B), HNK-BAc (C), and HNK-HAc (D) as indicated, in the presence of 1 mM L-dopa and 0.22 mM of carbidopa. The effects of each analog (left), on the proliferation were monitored at OD600 for 6 h and culture media were collected at indicated time points (dashed lines) for L-dopa and dopamine measurements. HPLC traces of representative samples and standards are shown in the middle left panel. The effects on L-dopa consumption and dopamine formation are shown respectively. *, P < 0.05 vs. control group at each collection time point. Data shown are the mean ± SD, n = 4.

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