Fig. 7 | Scientific Reports

Fig. 7

From: Identification of autoantibodies against HIF1a in patients with anorexia nervosa and their potential role in hepatic cytolysis

Fig. 7

Proposed Model of Anti-HIF1α Autoantibodies and Hepatic Cytolysis in Anorexia Nervosa. This figure summarizes hypothesis for the development of anti-HIF1α autoantibodies in anorexia nervosa (AN) and their contribution to hepatic cytolysis. Disruption of immune tolerance to HIF1a in anorexia nervosa (AN) may be due to autophagy dysregulation, imbalance in Th17/Treg regulation, production of pro-inflammatory cytokines, or post-translational modifications, enhancing HIF1a overexpression and/or immunogenicity. Hepato-cytolysis-induced HIF1a autoantibodies may involve: complement activation, pro-inflammatory cytokine release, apoptosis or oxidative stress induction. Hepatic cytolysis could also contribute to autoantibody generation, creating a potential feedback loop.

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