Table 1 Patient demographics and characteristics in cluster 1 and cluster 2 patients at biopsy and enrollment.
From: Defining subgroups of pediatric nephrotic patients with urine proteomics
Median (IQR) or N (%) | Cluster 1 (N = 71) | Cluster 2 (N = 17) |
|---|---|---|
Age at biopsy | 8 (4,13) | 9 (5,13) |
Age at enrollment | 10 (7,14) | 10 (6,13) |
Male | 44 (62%) | 11 (65%) |
Diagnosis | ||
MCD | 40 (56%) | 10 (59%) |
FSGS | 31 (44%) | 7 (41%) |
Race | ||
White | 34 (48%) | 9 (53%) |
Black | 21 (30%) | 6 (35%) |
Asian | 5 (7%) | 1 (6%) |
Other | 11 (15%) | 1 (6%) |
Hispanic | 9 (13%) | 0 (0%) |
Years between biopsy and enrollment | 0.7 (0.2, 2.6) | 0.4 (0.1, 1.5) |
eGFR at biopsy | 120 (87, 146) | 102 (83, 112) |
eGFR at enrollment | 97 (76, 117) | 105 (77, 141) |
UPCR at biopsy | 6.3 (2.5, 12.8) | 5.8 (1.9, 8.0) |
UPCR at enrollment | 4.0 (1.9, 9.2) | 3.6 (2.2, 6.9) |
Kidney failure during study follow up | 17 (24%) | 4 (24%) |
Kidney failure or 40% decline during study follow up (among those who didn’t hit 40% decline prior to cluster assignment N = 67) | 23/67 (34%) | 4/16 (25%) |
