Fig. 1
From: HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition
Effects of MCIT and HIIT on basic data and vascular function in atherosclerotic mice. The groups included wild-type mice (Control), ApoE KO HFD sedentary mice (AS-S), ApoE KO HFD mice undergoing moderate-intensity continuous training (AS-MICT), and ApoE KO HFD mice undergoing high-intensity interval training (AS-HIIT). Mice were trained on a treadmill following specific exercise protocols for 12 weeks. The following parameters were measured. Changes of (A) body weight were recorded. (B) T-SOD activity, (C) MDA, (D) GSH-Px, (E) TG, (F) TC, (G) HDL-C, and (H) LDL-C in the serum of mice were tested by kits. (I) Representative hematoxylin and eosin (HE)-stained images of aortas from each group. (J) and (K) The protein expression of eNOS in aortas was determined by western blotting. (L) ACh-induced relaxation and (M) SNP-induced relaxation of aortas were measured by vascular reactivity experiment. *P < 0.05, AS-S compared with Control; #P < 0.05, AS-MICT and AS-HIIT compared with AS-S. Data are presented as means ± SD.
