Table 1 Results of causal relationship between mtNDA-CN and Osteoporosis.
From: MR analysis reveals no causal association between mitochondrial DNA copy number and osteoporosis
Outcome | Exposure | N. SNPs | Methods | OR (95% CI) | P |
|---|---|---|---|---|---|
Femoral neck bone mineral density | Mitochondrial DNA copy number | 62 | IVW | 1.00 (0.89–1.12) | 0.988 |
MR-Egger | 0.94 (0.73–1.21)© | 0.618 | |||
Weighted Median | 0.94 (0.80–1.10) | 0.456 | |||
Weighted Mode | 0.89 (0.68–1.18) | 0.437 | |||
Lumbar spine bone mineral density | Mitochondrial DNA copy number | 62 | IVW | 1.00 (0.87–1.15) | 0.977 |
MR-Egger | 0.89 (0.66–1.20) | 0.438 | |||
Weighted Median | 1.02 (0.85–1.21) | 0.853 | |||
Weighted Mode | 0.96 (0.76–1.21) | 0.734 | |||
Forearm bone mineral density | Mitochondrial DNA copy number | 62 | IVW | 0.90 (0.70–1.16) | 0.421 |
MR-Egger | 0.70 (0.41–1.22) | 0.215 | |||
Weighted Median | 0.81 (0.59–1.12) | 0.200 | |||
Weighted Mode | 0.75 (0.50–1.12) | 0.165 | |||
Total body bone mineral density | Mitochondrial DNA copy number | 67 | IVW | 0.97 (0.89–1.05) | 0.427 |
MR-Egger | 1.09 (0.91–1.30) | 0.369 | |||
Weighted Median | 0.98 (0.87–1.11) | 0.766 | |||
Weighted Mode | 1.14 (0.93–1.40) | 0.207 |
