Table 1 Comparison of the present study with previous works.
Hydrogel Type | Synthesis Method and Raw Materials | Drug Type and Dose* | Release Control, Conditions, Amount | Notable Feature | Key Findings | Reference |
|---|---|---|---|---|---|---|
Thermosensitive hydrogel loaded with CS-CNT | Physical mixing, PEG, CL, CNT, CS | DOX DOX: CNT** (1:2) | NIR, 49% (7 days) PBS buffer (pH 7.4) at 37 °C | Photothermal effect, dual-stage release | NIR-triggered drug delivery, controlled drug release, in vivo fluorescence monitoring | |
PVA-CNT nanocomposite hydrogel | Freeze–thaw, PVA, COP, PVME, MWCNT (0.2 wt %) | Ibuprofen (5.3 mg) and 5-FU (4 mg) *** | NIR, 97% (6 h, 5-FU) and 79% (47 h, Ibuprofen) PBS buffer (pH 7.4) at 37 °C | Photothermal effect, dual drug release (hydrophilic and hydrophobic) | NIR-triggered drug release, Cytotoxicity in HeLa cancer cells | |
CNT–CS/pNIBBIm hydrogel | In Situ polymerization and freeze-drying, MWCNT (2.8 wt%), CS, NIPAAm, BBVIm | Ketoprofen LC: 380% | Electro-Thermal Stimuli, 37% (PBS buffer at 37 °C and 50 °C,18 days) | Electro-thermal responsive, conductive 3D network | Switchable and controlled release, non-toxic to Hs68 cells | |
Injectable CNT loaded nanocomposite silk hydrogel | Multi-step functionalization of CNT and blending, COOH-SWCNTs, FA, EDC, EDEA, BM, AA | DOX DOX: CNT (1:3) | Protease degradation, pH and temperature, 30–40% (14 days, protease) and 20% (at pH 4.5 and 45 °C) | Biocompatible silk fibroin, viscoelastic, injectable | Targeted, and on-demand delivery, SWCNT-FA/DOX induced apoptosis in KB cells | |
PAA-CNT nanocomposite hydrogel | In Situ polymerization, AAm and OH-MWCNT (0.16 wt%) | DOX LC: 5.11% | Acidic pH, PBS buffer (pH 7.4: 25.72%, pH 5.5:74.31%) at 37 °C (72 h) | Micro-network architecture, superior swelling behavior and structural stability, biocompatible | Sustained DOX release, cytotoxicity in MCF-7 cancer cells, non-hemolytic to RBCs | This work |
