Fig. 5 | Scientific Reports

Fig. 5

From: Leveraging diverse cell death patterns in osteosarcoma patients and identification of the function of FADS2 in osteosarcoma cells

Fig. 5

PCD model genes in single-cell of OS tissue. (A) Single-cell RNA sequencing analysis of osteosarcoma identifying seven distinct cell types (GSE162454). (B) Significant differences in CDI mean values among the seven cell types. (C) Expression and distribution of PCD model genes across cell types, showcasing heightened expression of PLEKHF1 in NK/T cells and predominant expression of FADS2 and CLTCL1 in osteosarcoma cells, myeloid cells, and cancer-associated fibroblasts (CAFs). (D, E) Validation of findings using the GSE152048 dataset, demonstrating consistent outcomes across different single-cell sequencing databases.

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