Fig. 1 | Scientific Reports

Fig. 1

From: Thymoquinone controlled obesity and invigorated cognitive and memory performance in rats consuming a high-fat diet via modulating oxidative stress, inflammation and apoptosis

Fig. 1

Effect of TQ and HFD on body weight changes (A) and body weight gain (%) (B). Data are shown as mean ± SEM (n = 6). H&E-stained fat tissue sections of control and different treated groups (C). Control and TQ-treated rats revealed normal arrangement and appearance of fat cells (asterisk) and nuclei (arrow) as well as blood vessels (arrowhead). Fat tissue section of the HFD group showed irregular appearance of fat cells represented by widened and swollen fat cells (red asterisk) with faded and ruptured cell membranes (tailed arrow), pyknosis (zigzag arrow), and congestion of blood vessels (curved arrow). Fat tissue section of the HFD + TQ-treated rats revealed a remarkable amelioration of fat cell structure and appearance compared to the HFD group. Quantification is expressed as the perimeter of visceral fat tissue (µm) in all studied groups. Each value represents the mean ± SEM of 5 microscopic fields/tissue samples.**,## Significant at P < 0.01, and ***,### Significant at P < 0.001. **, *** Indicate comparisons with respect to the control group. ##,### Indicate comparisons with respect to the HFD group. Cont : Control, TQ: Thymoquinone, HFD: High-fat diet, HFD + TQ: High-fat diet + Thymoquinone.

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