Table 6 Diagnostic performance of inflammatory markers in COM. Diagnostic performance of individual biomarkers (NLR, CRP, TNF-α, IL-6) and their combination for COM, including cut-off values, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), area under the curve (AUC), and 95% confidence intervals (CI) are provided for each marker. The P values represent the statistical comparison between the ROC curves for individual biomarkers and their combination.
From: Diagnostic value of neutrophil to lymphocyte ratio and serum biomarkers in chronic osteomyelitis
Variable | Cut-off values | Sensitivity | Specificity | PPV | NPV | AUC | 95% CI | P value |
|---|---|---|---|---|---|---|---|---|
NLR | 2.185 | 0.840 | 0.790 | 0.8 | 0.832 | 0.857 | 0.804–0.909 | < 0.001 |
CRP (µg/ml) | 7.065 | 0.870 | 0.940 | 0.935 | 0.878 | 0.930 | 0.891–0.969 | < 0.001 |
TNF-α (pg/ml) | 25.37 | 0.8 | 0.930 | 0.919 | 0.823 | 0.887 | 0.836–0.938 | < 0.001 |
IL-6 (pg/ml) | 5.920 | 0.750 | 0.980 | 0.974 | 0.797 | 0.923 | 0.887–0.959 | < 0.001 |
Combination | - | 0.930 | 1 | 1 | 0.935 | 0.988 | 0.974–1 | < 0.001 |
