Fig. 6

Immunohistochemical staining of ANP/CD13 expression in transplanted tumors. HT-29 grafts (A, B) exhibited no significant expression of ANP/CD13, whereas HT-1080 grafts demonstrated high expression of ANP/CD13 prior to treatment with ubenimex (indicated by arrows). Expression of ANP/CD13 was markedly reduced at 7 days post-treatment with ubenimex (indicated by arrows) (20×).