Table 1 Baseline clinical characteristics: semaglutide versus Dulaglutide.
From: Comparative cardiovascular outcomes of semaglutide to dulaglutide in patients with type 2 diabetes
Patients before matching | Propensity score matched patients | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Semaglutide | Dulaglutide | SMD | Semaglutide | Dulaglutide | SMD | |||||
(N = 231,075) | (N = 189,103) | (N = 171,105) | (N = 171,105) | |||||||
Age, mean (SD) | 59.2 | (12.3) | 59.3 | (12.4) | 0.009 | 59.4 | (12.2) | 59.3 | (12.4) | 0.005 |
Female, n (%) | 120,642 | (52.2) | 95,065 | (50.3) | 0.039 | 86,315 | (50.4) | 86,856 | (50.8) | 0.006 |
Body mass index, kg/m2, mean (SD) | 36.1 | (7.9) | 34.8 | (7.9) | 0.161 | 35.2 | (7.8) | 35.1 | (7.9) | 0.018 |
Race, n (%) | ||||||||||
Asian | 11,279 | (4.9) | 6,767 | (3.6) | 0.065 | 6,496 | (3.8) | 6,528 | (3.8) | 0.001 |
American Indian or Alaska Native | 807 | (0.3) | 830 | (0.4) | 0.014 | 721 | (0.4) | 677 | (0.4) | 0.004 |
Black or African American | 38,302 | (16.6) | 38,177 | (20.2) | 0.093 | 31,765 | (18.6) | 32,236 | (18.8) | 0.007 |
Native Hawaiian or Other Pacific Islander | 1837 | (0.8) | 954 | (0.5) | 0.036 | 915 | (0.5) | 922 | (0.5) | 0.001 |
White | 132,322 | (57.3) | 103,816 | (54.9) | 0.048 | 95,699 | (55.9) | 95,674 | (55.9) | < 0.001 |
Other Race | 8,546 | (3.7) | 7,814 | (4.1) | 0.022 | 6,893 | (4.0) | 6,887 | (4.0) | < 0.001 |
Unknown | 37,982 | (16.4) | 30,745 | (16.3) | 0.005 | 28,616 | (16.7) | 28,181 | (16.5) | 0.007 |
Diagnosis, n (%) | ||||||||||
Heart failure | 11,359 | (4.9) | 10,373 | (5.5) | 0.026 | 8,630 | (5.0) | 8,753 | (5.1) | 0.003 |
Ischemic heart diseases | 21,844 | (9.5) | 18,214 | (9.6) | 0.006 | 15,752 | (9.2) | 16,038 | (9.4) | 0.006 |
Previous myocardial infarction | 2,299 | (1.0) | 2,500 | (1.3) | 0.031 | 1,924 | (1.1) | 1,974 | (1.2) | 0.003 |
Atrial fibrillation and flutter | 9,510 | (4.1) | 8,022 | (4.2) | 0.006 | 6,874 | (4.0) | 7,043 | (4.1) | 0.005 |
Hypertension | 107,504 | (46.5) | 87,220 | (46.1) | 0.008 | 77,482 | (45.3) | 77,995 | (45.6) | 0.006 |
Dyslipidemia | 52,724 | (22.8) | 43,700 | (23.1) | 0.007 | 38,123 | (22.3) | 38,641 | (22.6) | 0.007 |
Chronic kidney disease | 21,155 | (9.2) | 18,763 | (9.9) | 0.026 | 16,095 | (9.4) | 16,197 | (9.5) | 0.002 |
Cerebral infarction | 2,793 | (1.2) | 3,131 | (1.7) | 0.038 | 2,388 | (1.4) | 2,479 | (1.4) | 0.004 |
Medication, n (%) | ||||||||||
Beta blockers | 30,294 | (13.1) | 31,040 | (16.4) | 0.093 | 25,213 | (14.7) | 25,608 | (15.0) | 0.006 |
Diuretics | 34,137 | (14.8) | 33,431 | (17.7) | 0.079 | 27,661 | (16.2) | 27,944 | (16.3) | 0.004 |
MRA | 4,995 | (2.2) | 4,512 | (2.4) | 0.015 | 3,866 | (2.3) | 3,867 | (2.3) | < 0.001 |
ACE inhibitors | 26,776 | (11.6) | 30,039 | (15.9) | 0.125 | 23,593 | (13.8) | 23,951 | (14.0) | 0.006 |
ARB | 28,426 | (12.3) | 23,744 | (12.6) | 0.008 | 21,214 | (12.4) | 21,238 | (12.4) | < 0.001 |
Sacubitril | 1,399 | (0.6) | 1,075 | (0.6) | 0.005 | 983 | (0.6) | 968 | (0.6) | 0.001 |
Statins | 60,456 | (26.2) | 59,736 | (31.6) | 0.120 | 49,666 | (29.0) | 49,931 | (29.2) | 0.003 |
Metformin | 60,782 | (26.3) | 58,548 | (31.0) | 0.103 | 49,709 | (29.1) | 49,859 | (29.1) | 0.002 |
Sulfonylureas | 19,262 | (8.3) | 23,199 | (12.3) | 0.130 | 17,869 | (10.4) | 18,169 | (10.6) | 0.006 |
SGLT2 inhibitors | 25,988 | (11.2) | 22,025 | (11.6) | 0.013 | 20,179 | (11.8) | 19,845 | (11.6) | 0.006 |
Insulin | 44,304 | (19.2) | 55,489 | (29.3) | 0.239 | 41,901 | (24.5) | 42,428 | (24.8) | 0.007 |
Laboratory | ||||||||||
Systolic blood pressure, mmHg, mean (SD) | 130 | (16.7) | 130 | (17.9) | 0.025 | 130 | (17.2) | 130 | (17.6) | 0.003 |
Diastolic blood pressure, mmHg, mean (SD) | 76 | (10.6) | 76 | (11.3) | 0.050 | 76 | (10.8) | 76 | (11.1) | 0.018 |
GFR, mL/min/1.73m2, mean (SD) | 76.2 | (28.0) | 74.5 | (29.9) | 0.060 | 75.3 | (29.2) | 74.8 | (29.3) | 0.017 |
Hemoglobin, g/dL, mean (SD) | 13.4 | (1.9) | 13.0 | (2.1) | 0.175 | 13.2 | (2.0) | 13.2 | (2.0) | 0.024 |
Albumin, g/dL, mean (SD) | 4.2 | (0.4) | 4.1 | (0.5) | 0.222 | 4.1 | (0.5) | 4.1 | (0.5) | 0.035 |
LDL cholesterol, mg/dL, mean (SD) | 90.5 | (38.0) | 90.7 | (39.8) | 0.003 | 90.4 | (39.0) | 90.5 | (39.4) | 0.002 |
HbA1c, %, mean (SD) | 8.2 | (1.8) | 8.8 | (2.0) | 0.332 | 8.6 | (1.9) | 8.7 | (1.9) | 0.009 |
