Table 2 Independent predictors of MACCE.

From: Eosinophil counts predict 3-year risk of major adverse cardiovascular and cerebrovascular events in carotid artery stenosis patients

Factor

Level

Univariable

Multivariate

OR (95% CI, P value)

OR (95% CI, P value)

Age

 

1.00 (0.98–1.02, p = 0.928)

 

Gender

Man

  

Woman

0.98 (0.68–1.41, p = 0.910)

 

Symptom

No

  

Yes

0.87 (0.60–1.28, p = 0.488)

 

SBP

 

1.01 (1.00–1.01, p = 0.065)

 

DBP

 

1.01 (1.00–1.02, p = 0.246)

 

Height

 

1.00 (0.98–1.01, p = 0.707)

 

Weight

 

1.00 (0.99–1.02, p = 0.650)

 

BMI

 

1.01 (0.99–1.03, p = 0.454)

 

Smoke

No

  

Yes

0.84 (0.60–1.19, p = 0.327)

 

Drunk

No

  

Yes

1.55 (1.11–2.18, p = 0.011)

 

Diabetes

No

  

Yes

0.91 (0.63–1.33, p = 0.641)

 

Hypertension

No

  

Yes

1.04 (0.73–1.47, p = 0.837)

 

Operation History

No

  

Yes

2.12 (1.51–2.98, p < .001)

1.66 (1.14 ~ 2.41, p < .008)

History of Stroke

No

  

Yes

1.64 (1.16–2.32, p = 0.005)

1.59 (1.10 ~ 2.31, p < .014)

Operation Mode

No

  

CEA

0.44 (0.06–3.35, p = 0.428)

 

CAS

2.14 (1.12–4.11, p = 0.051)

 

Carotid artery ultrasound

 Maximum plaque diameter

 

1.03 (0.86–1.24, p = 0.757)

 

 The branch with the largest plaque

Left

  

Right

1.04 (0.70–1.55, p = 0.848)

 

 The direction with the largest plaque

Left

  

Right

0.69 (0.49–0.96, p = 0.029)

 

 Maximum plaque length

 

1.03 (0.86–1.25, p = 0.743)

 

 Maximum plaque width

 

6.04 (1.54–23.71, p = 0.010)

 

 Maximum plaque area

 

1.35 (0.90–2.02, p = 0.147)

 

 LCCA

No

  

Yes

1.02 (0.69–1.48, p = 0.937)

 

 LICA

No

  

Yes

1.05 (0.73–1.52, p = 0.776)

 

 LECA

No

  

Yes

0.67 (0.37–1.23, p = 0.196)

 

 RCCA

No

  

Yes

1.18 (0.82–1.70, p = 0.363)

 

 RICA

No

  

Yes

0.97 (0.66–1.42, p = 0.866)

 

 RECA

No

  

Yes

1.16 (0.69–1.95, p = 0.579)

 

Laboratory values

 INR

 

0.99 (0.75–1.30, p = 0.944)

 

 FIB

 

0.99 (0.92–1.07, p = 0.774)

 

 APTT

 

1.00 (0.97–1.02, p = 0.763)

 

 D dimer

 

1.00 (1.00–1.00, p = 0.170)

 

 ALT

 

1.00 (1.00–1.00, p = 0.764)

 

 AST

 

1.00 (0.98–1.01, p = 0.771)

 

 TBIL

 

0.99 (0.96–1.02, p = 0.471)

 

 DBIL

 

1.03 (0.98–1.09, p = 0.284)

 

 IBIL

 

0.98 (0.95–1.01, p = 0.195)

 

 TP

 

0.98 (0.95–1.00, p = 0.025)

0.97 (0.95 ~ 0.99, p = 0.020)

 ALB

 

0.96 (0.93–1.00, p = 0.051)

 

 GLB

 

0.99 (0.98–1.01, p = 0.558)

 

 UREA

 

1.00 (0.99–1.01, p = 0.781)

 

 SCR

 

1.00 (1.00–1.00, p = 0.848)

 

 UA

 

1.00 (1.00–1.00, p = 0.404)

 

 K

 

1.11 (0.72–1.71, p = 0.624)

 

 Na

 

0.99 (0.97–1.02, p = 0.710)

 

 Cl

 

0.99 (0.96–1.02, p = 0.668)

 

 Ca

 

0.50 (0.13–1.91, p = 0.313)

 

 HCY

 

0.99 (0.97–1.00, p = 0.091)

 

 TC

 

1.00 (1.00–1.01, p = 0.374)

 

 TG

 

0.99 (0.90–1.08, p = 0.809)

 

 HDL.C

 

0.96 (0.75–1.24, p = 0.778)

 

 LDL.C

 

0.76 (0.61–0.96, p = 0.019)

 

 GLU

 

0.97 (0.91–1.04, p = 0.429)

 

 ESR

 

1.01 (1.00–1.02, p = 0.025)

1.01(1.00–1.02, p = 0.031)

 WBC

 

1.00 (0.99–1.01, p = 0.955)

 

 RBC

 

0.80 (0.61–1.05, p = 0.112)

 

 Hb

 

0.99 (0.99–1.00, p = 0.149)

 

 PLT

 

1.00 (1.00–1.00, p = 0.259)

 

 LYM

 

0.81 (0.64–1.04, p = 0.095)

 

 MONO

 

1.30 (0.52–3.23, p = 0.574)

 

 NEUT

 

1.00 (0.97–1.02, p = 0.686)

 

 EO

 

4.03 (1.65–9.84, p = 0.002)

4.62 (1.60 ~ 13.35, p = 0.005)

 BASO

 

0.74 (0.06–8.71, p = 0.814)

 

 LYMR

 

0.99 (0.97–1.01, p = 0.165)

 

 MONOR

 

1.01 (0.97–1.05, p = 0.707)

 

 NEUTR

 

1.00 (0.99–1.02, p = 0.512)

 

 EOSR

 

1.05 (1.00–1.10, p = 0.072)

 

 BASOR

 

0.86 (0.52–1.40, p = 0.537)

 

Medications

 Antiplatelet Hypoglycemic

No

  

Yes

1.06 (0.72–1.56, p = 0.754)

 

 Aspirin

No

  

Yes

0.89 (0.62–1.29, p = 0.547)

 

 Clopidogrel

No

  

Yes

1.03 (0.74–1.45, p = 0.845)

 

 Antiplatelet

No

  

Yes

1.17 (0.83–1.65, p = 0.378)

 

 Hypoglycemic

No

  

Metformin + Acarbose

2.18 (1.43–3.33, p < 0.001)

 

Insulin

0.72 (0.22–2.38, p = 0.587)

 

 Hypoglycemic Antihypertensive

No

  

Yes

1.16 (0.77–1.74, p = 0.477)

 

 Metformin

No

  

Yes

0.76 (0.46–1.25, p = 0.278)

 

 Acarbose

No

  

Yes

0.73 (0.43–1.24, p = 0.240)

 

 Antihypertensive

No

  

CCB + BBs

4.01 (2.78–5.77, p < 0.001)

3.08 (2.04 ~ 4.63, p < 0.001)

CCB + ACEI/ARBs

0.00 (0.00-Inf, p = 0.980)

 

 CCBs

No

  

Yes

3.06 (2.15–4.38, p < 0.001)

 

 BBs

No

  

Yes

4.22 (2.93–6.08, p < 0.001)

 

 ACEI/ARBs

No

  

Yes

0.00 (0.00-Inf, p = 0.979)

 

 Antihypertensive Antiplatelet

No

  

Yes

1.18 (0.84–1.65, p = 0.340)

 

 Nifedipine

No

  

Yes

0.58 (0.38–0.87, p = 0.008)

 

 Hydrochlorothiazide

No

  

Yes

1.34 (0.73–2.44, p = 0.342)

 

 Metoprolol

No

  

Yes

0.94 (0.56–1.57, p = 0.800)

 

 Valsartan

No

  

Yes

1.15 (0.70–1.89, p = 0.579)

 
  1. Each factor was analyzed separately, and then factors independently associated with MACCE were selected and included in the multivariate analysis (P < 0.05).
  2. CI confidence interval.
  3. Significant values are in bold.
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