Fig. 8 | Scientific Reports

Fig. 8

From: High glucose inhibits proliferation, migration, and osteogenic differentiation of human placenta-derived mesenchymal stem cells

Fig. 8

NanoString nCounter analysis shows the effect of high glucose on the gene expression profile of hP-MSCs. (A) Heatmap of the hierarchical cluster analysis shows the gene expression profiles of hP-MSCs treated with 25 mM D-glucose for 7 days compared to control (5.5 mM). (B) Volcano plot shows genes that are upregulated under high glucose conditions. Notable examples include FLT1, ITGA11, VEGFA, and COL6A1, which are involved in glutamine metabolism and DNA damage repair. Data represent fold changes determined by NanoString nCounter analysis, with p-values indicating statistical significance compared to the control (5.5 mM). (C) Gene enrichment analysis shows significantly up- and down-regulated genes under high glucose conditions.

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