Table 2 Unadjusted and adjusted Cox regression analysis for the combined event of heart failure readmission and all-cause mortality.

From: Prognostic value of symptom burden as a simple patient-reported outcome measure in older patients with heart failure

 

Unadjusted Cox model

Adjusted Cox model

Model 1 (baseline model)

Model 2

Variable

HR

95% CI

p Value

HR

95% CI

p Value

HR

95% CI

p Value

ESAS score (per 5 point increase)

1.12

1.05

-

1.18

< 0.001

1.10

1.04

-

1.17

< 0.001

1.11

1.05

-

1.18

< 0.001

Tertiles of ESAS sum score

Low burden (point 0–7)

1.00

[Reference]

 

1.00

[Reference]

 

1.00

[Reference]

 

Intermediate burden (point 8–19)

1.73

1.01

-

2.94

0.045

1.76

1.03

-

3.01

0.038

1.84

1.07

-

3.15

0.028

High burden (point ≥ 20)

2.12

1.26

-

3.54

0.004

2.12

1.26

-

3.55

0.004

2.32

1.36

-

3.95

0.002

  1. Model1: adjusted for MAGGIC risk score and log BNP.
  2. Model2: Model 1plus, GNRI, handgrip strength, and MMSE score.
  3. BNP B-type natriuretic peptide, CI confidence interval, ESAS Edmonton Symptom Assessment System, GNRI geriatric nutritional risk index, HR hazard ratio, MAGGIC Meta-analysis global group in chronic heart failure risk score, MMSE Mini-mental state examination.
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