Table 2 Subgroup analysis of the joint association of TyG and SII levels with all-cause mortality in NHANES 1999–2018.

From: Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortality

Subgroup

N (events)

Low TyG & LowSII

High TyG & Low SII HR (95%CI)

Low TyG & High SII HR (95%CI)

High TyG & High SII HR (95%CI)

p value

p for interacti-on

Overall

1287

ref

1.15(1.00,1.33)

1.21(1.07,1.38)

1.29(1.16,1.44)

 < 0.001

–

Age

      

 < 0.001

 ≤ 60

245

ref

1.63(1.23,2.18)

1.11(0.86,1.44)

1.81(1.41,2.33)

 < 0.001

 

 > 60

1042

ref

1.03(0.90,1.18)

1.35(1.16,1.57)

1.27(1.12,1.43)

 < 0.001

 

sex

      

 < 0.001

Male

606

ref

1.43(1.19,1.72)

1.64(1.36,1.99)

1.69(1.42,2.01)

 < 0.001

 

Female

681

ref

1.80(1.39,2.34)

1.22(0.96,1.54)

2.26(1.82,2.82)

 < 0.001

 

BMI

      

0.030

24 ~ 27.9

360

ref

1.31(1.05,1.64)

1.12(0.87,1.45)

1.55(1.27,1.89)

 < 0.001

 

 < 23.9

246

ref

1.52(1.17,1.99)

1.26(1.01,1.58)

1.80(1.42,2.28)

 < 0.001

 

 ≥ 28

681

ref

1.74(1.30,2.33)

1.75(1.40,2.18)

2.59(2.02,3.31)

 < 0.001

 

Edu

      

0.020

Above high school

464

ref

1.36(1.02,1.80)

1.25(1.01,1.54)

1.95(1.58,2.40)

 < 0.001

 

Under high school

335

ref

1.51(1.16,1.96)

1.50(1.14,1.98)

1.67(1.31,2.13)

 < 0.001

 

High school or equivalent

488

ref

1.87(1.43,2.43)

1.46(1.12,1.90)

2.06(1.61,2.63)

 < 0.001

 

DM

      

 < 0.001

No

728

ref

1.35(1.11,1.65)

1.34(1.15,1.56)

1.77(1.53,2.04)

 < 0.001

 

Yes

559

ref

1.02(0.77,1.36)

1.51(1.09,2.09)

1.15(0.87,1.51)

0.330

 

Hyperlipidemia

      

 < 0.001

Yes

1181

ref

1.30(1.09,1.55)

1.22(1.01,1.47)

1.58(1.35,1.84)

 < 0.001

 

No

106

ref

2.26(1.56,3.29)

1.76(1.39,2.23)

2.88(2.15,3.86)

 < 0.001

 

Hypertension

      

 < 0.001

Yes

949

ref

1.21(1.00,1.45)

1.41(1.17,1.69)

1.45(1.25,1.68)

 < 0.001

 

No

338

ref

1.54(1.19,2.01)

1.10(0.87,1.38)

1.76(1.43,2.15)

 < 0.001

 
  1. HR hazard ratio, CI confdence interval, BMI body mass index, TyG triglyceride–glucose index, SII Systemic Inflammation Index, CVD cardiovascular disease.
  2. Median TyG index: 8.618; Median SII: 466.667.
  3. HR, 95% CI and p-values are based on Cox proportional hazards regression Model 3.
  4. The p-value refers to the statistical significance of the HR for the High TyG & High SII category compared to the reference group (Low TyG & Low SII).
  5. The event represents the number of individuals with positive outcomes in High TyG and High SII group.
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