Fig. 1 | Scientific Reports

Fig. 1

From: Homocysteine promotes cardiomyocyte hypertrophy through inhibiting β-catenin/ FUNDC1 mediated mitophagy

Fig. 1

Homocysteine suppressed the expression of β-catenin and mitophagy-related proteins in the myocardium, and induced cardiac hypertrophy. (A) Western blot analyses showed the expressions of protein, including β-catenin, active β-catenin, FUNDC1, LC3II/LC3I, p62 in the hearts of mice subjected to hyperhomocysteinemia for 4 weeks. (B–F) Quantitative data on β-catenin, active β-catenin, FUNDC1, LC3II/LC3I, p62 proteins in indicated groups. Relative levels of protein were presented as fold induction over the controls. (G) Western blot analyses showed the expressions of protein including α-actin, β-MHC in the hearts of mice subjected to hyperhomocysteinemia for 4 weeks. (H,I) Quantitative determination of α-actin, β-MHC in (G). *P < 0.05 versus the controls (n = 6).

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