Fig. 3
The identification of target genes directly regulated by the key blood miRNAs from the three datasets by bioinformatics analysis. (A) The principal BPs, MFs, and CCs of down-regulated miRNAs and corresponding up-regulated target genes. (B) The principal BPs, MFs, and CCs of up-regulated miRNAs and corresponding down-regulated target genes. (C) Signalling pathway enrichment results of up-regulated miRNAs and corresponding down-regulated target genes in KEGG (The permission to use KEGG software has been obtained from Kanehisa Laboratories). (D) Signalling pathway enrichment results of down-regulated miRNAs and the corresponding up-regulated target genes in KEGG. (E) Network of target gene-encoded proteins corresponding to all 20 most significantly differentially expressed blood miRNAs.
