Fig. 6
The expression levels of key miRNAs and clinical markers in CagA-positive patients’ blood specimens by RT-qPCR detection. (A) CagA was remarkably overexpressed in human GC blood specimens compared to the normal controls (P < 0.05). (B) The expression pattern of five key miRNAs in CagA-positive blood samples from GC patients, which showed up-regulation of hsa-miR-124-3p and hsa-miR-29b-3p, as well as down-regulation of hsa-miR-125-3p, hsa-miR-4276, and hsa-miR-575. (C) The clinical markers expression levels including Ki67, E-Cadherin, CK19, and Her-2 in CagA-positive blood samples, while the expression of E-Cadherin and Her-2 showed down-regulated. (D) The clinical markers expression levels including AFP, CEA, CA19-9, CA125 and CA72-4 in CagA-positive blood samples. None of them determined overexpression.
