Fig. 6 | Scientific Reports

Fig. 6

From: Pharmacologic inhibition of BMI1 exerts antitumor effects against MYCN-amplified neuroblastoma, with activation of the p53 pathway

Fig. 6

Antitumor effects of PTC-028 on human tumor xenograft models. (A) Protocol for analysis of the effect of PTC-028 treatment on human tumor xenograft models. (B) Representative photographs of mice and tumors 14 days after the commencement of treatment. Photographs of all of the mice before tumor dissection and photographs of all of the dissected tumors are shown in Figure S12. The raw measurements of the tumors for every mouse are shown in Table S6. (C) Tumor volume of the control group and PTC-028 group monitored for 14 days. Data are presented as mean ± SE (n = 6; *p < 0.05, **p < 0.01; two-way ANOVA). (D) Weight of excised tumor in each group after 14 days of treatment. Data are presented as mean ± SE (n = 6; *p < 0.05, **p < 0.01; Student’s t-test). (E) Body weight of mice after tumor excision at 14 days after the commencement of treatment (n = 6; *p < 0.05, **p < 0.01; Student’s t-test).

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