Table 3 Mediation analysis for HADS and EORTC QLC C-30 scales with AAQ-II as mediator.

Direct effects

 HADSD → cognitive function

− 3.13

0.66

− 4.68

< 0.001

[− 4.45, − 1.80]

 HADSD → emotional functioning

− 3.10

0.61

− 5.03

< 0.001

[− 4.33, − 1.88]

 HADSD → social functioning

− 3.85

0.77

− 4.99

< 0.001

[− 5.38, − 2.32]

 HADSD → dyspnoea

1.99

0.73

2.69

0.008

[0.52, 3.46]

 HADSD → insomnia

1.87

0.96

1.93

0.055

[− 0.04, 3.79]

 HADSA → cognitive function

− 1.33

0.63

− 2.10

0.03

[− 2.59, − 0.07]

 HADSA → social functioning

− 1.38

0.74

− 1.85

0.06

[− 2.86, 0.09]

Indirect effects

 HADSD → AAQ− II → cognitive function

− 0.99

0.42

[− 1.93, − 0.25]a

 HADSD → AAQ-II → emotional functioning

 HADSD → AAQ-II → social functioning

− 1.38

− 0.74

0.43

0.44

[− 2.30. − 0.55]a

[− 1.79, − 0.03]a

 HADSD → AAQ-II → dyspnoea

1.24

0.50

[0.28, 2.29]a

 HADSD → AAQ-II → insomnia

1.08

0.53

[0.18, 2.27]a

 HADSA → AAQ-II → cognitive function

− 1.27

0.45

[− 2.16, − 0.38]a

 HADSA → AAQ-II → social functioning

− 1.20

0.54

[− 2.29, − 0.14]a