Fig. 3

Associations between BRI levels and brain white matter integrity. The relationships between BRI levels and the integrity of white matter tracts were evaluated using multiple linear regression models among 27,361 participants with available MRI data from the UK Biobank. The mean diffusivity (MD), and isotropic volume fraction (ISOVF) of white matter tracts were utilized as reference metrics. Results are presented as β values, with significance determined by FDR-corrected P values. Furthermore, the results of stratified analyses by sex are presented on the right. Regions marked in red denote positive correlations. The brain structure marked with an asterisk indicates a statistically significant association.